Pharmaceutical companies are constantly trying to find a way to avoid the side effects of the drugs, thus the attention is leaning towards the research of peptides. [J. Med. Chem., 2018, 61, 1382]
To synthesize a variety of novel peptides natural amino acids are not enough, therefore usage of synthetic amino acids in peptide synthesis is gaining popularity. [Biochimica et Biophysica Acta, 2017, 1861, 3024]
The goal of this project is to use 3-pyrrolidinone to form novel heterocyclic amino acids with a pyridine moiety. Pyridine moiety was chosen because its derivatives are important in medicinal chemistry and used as an active ingredient in drugs. [J. of Drug Design and Med. Chem., 2015, 1, 1]
During the project the attempts to find optimal synthesis of pyridine moiety containing amino acids, will be made. Synthesized amino acids will be optimal for the synthesis of novel peptides.
Project funding:
Project is funded by EU Structural Funds according to the 2014–2020 Operational Programme for the European Union Funds’ Investments priority “Development of scientific competence of researchers, other researchers, students through practical scientific activities” under Measure No. 09.3.3-LMT-K-712.
Project results:
The expected outcome of the projects – novel amino acids, which might be used in peptide synthesis. While working on the project, the junior researcher will gain knowledge and practical experience in the promising field of heterocyclic amino acids synthesis and research. The results of the project will be presented in the scientific conference.
Period of project implementation: 2018-10-01 - 2019-04-30
Project coordinator: Kaunas University of Technology
