Heterocyclic compounds are widely used across various fields, including medicine, agriculture, and materials science. Among them, condensed heterocyclic compounds, i.e., molecules in which two or more rings share adjacent atoms and at least one ring is heterocyclic, are particularly relevant. Such compounds are often used in the development of pharmaceutical materials, as condensed systems are highly stable and heteroatoms can form various bonds with biological targets. Furthermore, by varying the size of the cyclic systems and the heteroatoms and their positions in the cyclic systems, it is possible to achieve optimal interactions between biologically active substances and targets.
During the planned summer internship, the student will synthesize condensed heterocyclic systems containing at least one pyrazole ring and analyze the structures of the resulting compounds. The student will learn to work with various organic synthesis methods and will perform reactions both under normal conditions and using microwave initiation. Various catalysts and inert reaction conditions will be used. Student will also learn methods for working up the organic reactions and purifying products: extraction, crystallization, distillation, and chromatographic purification. Nuclear magnetic resonance spectroscopy, mass spectrometry, and infrared spectroscopy will be used to analyze the structures of the compounds. The new condensed heterocyclic systems obtained will be investigated for biological activity (preliminary neuroprotective) in collaboration with researchers at other institutions.
Project results:
Based on the summer internship results, presentations will be prepared for the conference materials.
Period of project implementation: 2026-07-01 - 2026-08-31
Project coordinator: Kaunas University of Technology
