One of the challenges of the modern world is the continuously increasing number of infections caused by antibiotic-resistant bacteria. Aiming to extend and expand research on N-substituted amino acid transformations, this project sets out to synthesize new N-(5-chloro-2-pyridyl)-?-alanine cyclization products into azole derivatives, thereby incorporating pyridine, amino acid, and azole fragments within a single molecule, and to evaluate the biological activity of these structurally designed compounds under laboratory conditions. Resistance to antimicrobial agents is recognized by the World Health Organization as one of the top ten threats to human public health. Although chemists have been refining well-known and developing new methodologies for pyridine derivative synthesis for over a century, interest in this field is unlikely to diminish soon, as pyridine-containing compounds continue to find widespread applications in both biological systems and the chemical industry. The goal of this project is the development and investigation of targeted synthesis methods for new biologically active 1,2,4-triazole derivatives containing a 5-chloropyridine fragment, modified with aromatic and heterocyclic aldehydes, exhibiting antimicrobial properties.
Project funding:
Project is funded by EU Structural Funds according to the 2014–2020 Operational Programme for the European Union Funds’ Investments priority “Development of scientific competence of researchers, other researchers, students through practical scientific activities” under Measure No. 09.3.3-LMT-K-712.
Project results:
The expected outcome of the project is the development of new arylideneamine derivatives exhibiting antimicrobial properties. The results obtained during the implementation of the planned activities will be presented at a student scientific conference organized by the implementing institution, and a comprehensive report on the completed scientific research will be submitted.
Period of project implementation: 2021-09-01 - 2022-03-31
Project coordinator: Kaunas University of Technology
