Chronic and complicated wounds remain a significant public health challenge due to prolonged healing, biofilm formation, and the increasing prevalence of antimicrobial resistance. Most currently used wound care solutions act non-specifically and are not adapted to the individual parameters of the wound microenvironment, therefore failing to ensure a differentiated therapeutic effect.
The proposed project aims to integrate biomimetic Ca–Mg–P materials engineering with pharmaceutical formulation technology in order to develop a film-forming system based on natural polymers. This matrix will incorporate metal-modified carbonated calcium phosphates (monetite and AB-type hydroxyapatite) obtained by microwave synthesis, which can function as a controllable source of bioactive ions. Such a system will form an in situ therapeutic matrix capable of simultaneously acting as a protective barrier, maintaining a moist wound environment, and enabling the controlled release of Ca2+, Zn2+, and Mg2+ ions.
During the project, the microwave synthesis of carbonated calcium phosphates will be optimized, and the influence of metal ions on the structure and functional properties of the resulting phases will be investigated. In addition, a film-forming gel formulation will be developed, and its physicochemical, mechanical, and barrier properties will be evaluated. Ion release profiles will also be experimentally modeled and analyzed, including their dependence on biomineral phase composition and the pH of the microenvironment.
The expected outcome of the project is the development of film-forming gels based on natural polymers with integrated synthetic calcium phosphates.
Project funding:
KTU fund for internal investment
Period of project implementation: 2026-04-01 - 2026-12-31
Project partners: Lithuanian University of Health Sciences
