L-proline is one of twenty naturally occurring amino acids which can form proteins via peptide bonding. Scientists are using peptides in development of novel drug molecules increasingly more often because peptide-based molecules tend to show more activity in clinical trials than low molecular weight molecules. [J. Med. Chem., 2018, 61, 1382] In order to increase potential uses of peptides in drug development, synthetic amino acids are being incorporated into their structure. [Biochimica et Biophysica Acta, 2017, 1861, 3024] New synthetic amino acids are usually made by modifying naturally occurring compounds. Scientists in prof. dr. Algirdas Šačkus group have recently started investigating L-proline modifications by introducing small selenazole ring in side chain of the molecule. [Chem. of Het. Comp., 2018, 54, 469] This research is going to be continued by forming thiazole ring instead of selenazole. The main goal of this research is to create a wider variety of synthetic amino acids.
Project funding:
Project is funded by EU Structural Funds according to the 2014–2020 Operational Programme for the European Union Funds’ Investments priority “Development of scientific competence of researchers, other researchers, students through practical scientific activities” under Measure No. 09.3.3-LMT-K-712.
Project results:
The expected result of this project is to obtain new enantiopure amino acids which could be applied in synthesis of novel peptides
Period of project implementation: 2018-10-01 - 2019-04-30
Project coordinator: Kaunas University of Technology
