When it comes to developing new active pharmaceutical ingredients, science is always involved in a never-ending race with nature. Microorganisms adapt and genetically mutate to become drug-resistant, and scientists create and modify molecules to defeat them. At the same time, studies on the synthetic strategies towards desired heterocyclic compounds remain relevant. N-heterocycles is common structural unit in biologically active compounds.
In this project, 1H-indol-3-ylacetic acid and its analogues were chosen as the research object. 1H-Indol-3-ylacetic acid is the most common auxin involved in regulating plant cell growth, division, and differentiation and helping plants adapt to changing environmental conditions. 1H-Indol-3-ylacetic acid and its derivatives and analogs are currently receiving increasing attention from pharmaceutical researchers. As research expands, there is a need for more diverse analogs such as those having various substituents at the 4-, 5-, 6-, or 7-position of the indole ring. To meet it, a reliable and uncomplicated synthesis procedure is required. One of the attractive methodologies is the application of the Fisher indole synthesis principle. The aim of this project is to optimize the conditions for the synthesis of 1H-indol-3-ylacetic acid using the Fisher indole synthesis method and to perform the synthesis of its analogues under optimal conditions. At the end of the project, all final products will be sent for bio-testing to our scientific partners in Czech Republic.
Project funding:
Project is funded by EU Structural Funds according to the 2014–2020 Operational Programme for the European Union Funds’ Investments priority “Development of scientific competence of researchers, other researchers, students through practical scientific activities” under Measure No. 09.3.3-LMT-K-712.
Period of project implementation: 2020-11-03 - 2021-04-30
Project coordinator: Kaunas University of Technology
