Bioprocess Research Centre

About

Bioprocess Research Centre

The Bioprocess Research Centre (BRC) focusses on the application of genetic engineering technologies and development of novel biocatalytic processes, which will enable to improve the microorganism-based production and conversion of waste streams into value-added products.

The research activities of BRC align closely with the multidisciplinary areas of synthetic biology, biotechnology, bioeconomy, and sustainable innovation. Currently, the research is supported by the European Regional Development Fund under grant agreement with the Research Council of Lithuania.

Team

The BRC team:

Prof. Dr. Naglis Malys (Chief Researcher, Head of BRC)
Assoc. Prof. Dr. Ilona Jonuškienė (Senior Researcher)
Assoc. Prof. Dr. Michail Syrpas (Research Associate)
Dr. Eglė Valančienė (Research Associate)
Ernesta Augustinienė (Research Assistant)
Ingrida Kutraitė (Research Assistant)
Paulius Matulis (Research Assistant)

Research

Field of Science: N 003 Chemistry, P 004 Biochemistry, T 005 Chemical Engineering

Main research areas:

Bioprocess analysis and development
Discovery and development of novel biocatalysts
Development and application of novel biocatalytic processes
Genome mining and biochemical pathway analysis
Gene expression regulation
Identification and application of inducible gene expression systems
Development and application of genetically-encoded biosensors
Genetic and metabolic engineering
Development of synthetic biology tools and methods
Microbial biotechnology and its application for natural products
Waste and C1 gas biotransformation into value-added products

Recent publications

Augustiniene, E., Malys, N. Identification and characterization of L- and D-lactate-inducible systems from Escherichia coli MG1655, Cupriavidus necator H16 and Pseudomonas species (2022) Scientific Reports, 12 (1), art. no. 2123.
Matulis, P., Kutraite, I., Augustiniene, E., Valanciene, E., Jonuskiene, I., Malys, N. Development and Characterization of Indole-Responsive Whole-Cell Biosensor Based on the Inducible Gene Expression System from Pseudomonas putida KT2440 (2022) International Journal of Molecular Sciences, 23 (9), art. no. 4649.
Augustiniene, E., Valanciene, E., Matulis, P., Syrpas, M., Jonuskiene, I., Malys, N. Bioproduction of l- and d-lactic acids: advances and trends in microbial strain application and engineering (2022) Critical Reviews in Biotechnology, 42 (3), pp. 342-360.